PF11 moves fast, wears camouflage and is comfortable operating in almost any terrain.
At our institute, we categorise FirstWave PF11 alongside the H5N1 and the 1918 pandemic strains as an Interferon-Deranging, Rapid Replicating Virus strain (IDRRV). The similarities between PF11, today’s Avian Influenza H5N1 and the 1918 strains are quite unappealing, but must be communicated. The SecondWave viral strain cannot be characterised until we see a stable genotype in the coming months because this present virus is persistent in acquiring new genetic material. Although most Influenza-suspect pandemics / plagues that we’ve reviewed in history demonstrate marked clinical differences in the first and second waves, we prefer to measure rather than speculate on this “once in a century” event. Science measures. Measurement may only occur during or after an event.
This virus carries the genetics for extreme illness, sudden death and long-term sequelae (complications) for survivors . . . and PF11 has connections to advance genetically. The circulating strains have clinically demonstrated a destructive multi-tropism (6 major human tissue types at last count), an ability to temporarily deactivate the immune system (interference of a required early cytokine-mediated process) and a swift speed of replication. By having a “head-start” on the body after immediately blunting the immune system and then using the added feature of rapid reproduction, PF11 initially gains a solid grasp in the throat and lungs.
Then the multi-tropism, like H5N1 and 1918, gives the PF11 virus an ability to attack multiple organ systems individually or simultaneously creating a wider battleground inside the host than a typical immune system can manage, culminating at times in a fatal outcome. Many patients demonstrate no fever until after they have deeply progressed (50% - Chile, 33% - Mexico), showing that the first warning signal for Influenza may not occur. The virus has the binding ability to enter many types of organs and has now been documented as using the bloodstream for transport.
What is FirstWave PF11 doing today?
For additional background on the clinical and epidemiological observational facts concerning Pandemic Influenza H1N1, please refer to the Table of Contents for PF11 Trends & Issues, Mid-Term.
